Winter approaches, time to fire up some Boinc
, use yr computer participate in some big science - in the cold world, computer cycles heat your house and solve some big problems..
Caenorhabditis elegans is known for his high rate of selfing that may make it susceptible to the operation of Muller's ratchet. Now evolution@home has found that this worm would indeed be in trouble if there were no processes that would counter genomic decay in this worm or if selfing was very old. we conclude that pure selfing can persist for only short evolutionary intervals, and is expected to lead to extinction within thousands of years for a plausible portion of parameter space. Credible lower-bound estimates of nuclear mutation rates do not extend the expected time to extinction much beyond a million years. biomedcentral existing simulation results suggest that outcrossing rates of less than 1% do not reduce the rate of mutation accumulation substantially ... existing simulation results suggest that outcrossing rates of less than 1% do not reduce the rate of mutation accumulation substantially
C.Elegans can only be thousands of years as selfing??
[I am not convinced by Muller's ratchet. Mystified how mitochondria can persist for 2B years with no crossing ]
Earthquakes Apple laptops manufactured since 2005 are outfitted with accelerometers, as are many IBM (now Lenovo), Acer, and HP laptops. They detect sudden acceleration--as when a laptop falls from a table, for instance--and brace the hard drive for impact. Quake Catcher Network's software analyzes shakes sensed by a computer's accelerometer and report only big movements to the central server, ignoring the vibrations from a passing truck, a bump to a table, or even a minor earthquake. The pattern of signals received by the server allows the network to recognize a significant earthquake.
Primes primegrid n 19 Apr 2012, 21:12:27 UTC, PrimeGrid’s Generalized Fermat Prime Search, through PRPNet, found the mega prime: 773620^262144+1 The prime is 1,543,643 digits long and enters Chris Caldwell's “The Largest Known Primes Database” ranked 2nd for Generalized Fermat primes and 22nd overall. The discovery was made by Senji Yamashita of Japan using an NVIDIA GeForce GTX 580 in an Intel Core i7-970 @ 3.20GHz system with 6GB RAM, running Windows 7 Professional x64. This GPU took about 47 minutes to probable prime (PRP) test with GenefCUDA. Senji is a member of the PrimeSearchTeam. ega prime: 773620^262144+1 (2^18 = 262144)
I'm running this, only 3,300 others, an interest in proving primality, somewhat recondite.. primaboinca seeking counterexample to Agrawal conjecture primaboinca targets reached: no counterexample for n < 10^11; next target: 10^11- 10^12; imath If Agrawal's conjecture were true, this would improve the polynomial time complexity of the AKS primality testing algorithm Lenstra and Pomerance and suggest strongly that this conjecture is false. efmer berkeleyin boinc unitedboinc _________________________________________________________________
thanks JulianA, great interview Hezbollah seems to startle itself with its successes. Their fuel-air device in Beirut killed so many US marines that Reagan pulled out of Lebanon.
In 2006 Hez snatched a couple of IDFers and then surprised everyone (including themselves?) by resisting invasion for weeks. I suspect that fibre-optics and actual cryptography were used, not just the farm-boy ciphers that SN claimed rt _________________________________________________________________
wafa Hundreds of Palestinians Arrested in March, says Rights Group NABLUS, April 11, 2012 (WAFA)..... One woman was arrested in Hebron under the pretext she attacked soldiers while crossing a checkpoint after soldiers took her 3-year-old son away from her.
The Genome Generation by Elizabeth Finkel 2012 Melbourne book review.
On first glimpse, another chatty pos sci book. On closer inspection a solid and startling investigation of C21 genetic revelations. EF is an ex research scientist, which typically means a book is solid. With a heap of references, many http (buy the kindle version?) This book is startling. I thought I had been keeping up with popular science news about the Genome, but I had fallen behind. Starts with an intro chapter, about that Saturday in 1953 - in the morning we were in the medieval vitalistic dark, in the afternoon we had a view of how molecules did life. Turns out the new 'Dogma' was over-rated. Only 1.5% of the human genome codes for protein. Chap2: "Junk is telling us something" One of EF's heroes is John Mattick (Melbourne?) sciencemag
The Eukaryotic Genome as an RNA Machine the genomes of all studied eukaryotes are almost entirely transcribed, [in various cell lines?] generating an enormous number of non–protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. EF says 8% of our DNA is fossil retrovirus and 45% are transposons (jumping genes) (others think the LINE etc may be retroviral traces, so over half , ie including the retrotransposons may be retroviral traces? .... virolution)".. Melbourne Simons: nature Rett Syndrome fugu fish have less junk DNA, but they do have some. Bacteria: 20% of genes are regulatory proteins
This is the sticking point: if it takes genes to make proteins to regulate genes, there is evidently a limit to complexity. Is this why multicell took billions of years to arrive?
Junk DNA Amoeba 50% roundworm 75% humans 98.5%
have we reached another sticking point of complexity, even using small RNA controllers? 1993: C elegans missing vulva if micro RNA lin-4 not present (22Base RNA from 70 Base DNA)
Its Double strand RNA (dRNA) that interferes , the cell recognises dRNA , DICER chops it into 20 base segments, RISC uses these to halt RNA expression. (plants,fungi,worms,flies). So far not useful medically, dRNA is fragile. in Humans 125 base miRNA protects against transposons oxfordjournals 2007 However, only a small proportion of these retroelements 0.05%, remains able to transpose...
among the non-long terminal repeat (LTR) retrotransposons, only some long interspersed nucleotide elements-1 (LINE-1, or L1) and short interspersed element (SINE) (Alu and SVA) subfamilies continue to be mobile in mammals today (1,2). sciencewatch miRNAs A Macro View of MicroRNA
nobelprize RNA interference ENCODE Project nytimes ‘Gene’ Has a Multitude of Meanings